Genomic variants-driven drug repurposing for tuberculosis by utilizing the established bioinformatic-based approachShort communication Published on 2022-12-012022-10-05 Journal: Biochemistry and Biophysics Reports [Category] 신약개발, [키워드] annotations applied approach bioinformatics biological process CCR5 CD44 cellular component contribute CXCR4 demonstrated deregulation disease disease-associated drug Drug discovery Drug repurposing drug target evaluated Evidence facilitate functional functional annotation Genes genomic genomic variant genomic variants GWAS HLA-B identify implementation in-silico indication involved KEGG Missense mutation molecular overlapped Pathogenesis Pathway analysis provided risk SELP suggested target Treatment Tuberculosis variant [DOI] 10.1016/j.bbrep.2022.101334 [Article Type] Short communication
Effect of the change in antiviral therapy indication on identifying significant liver injury among chronic hepatitis B virus infections in the grey zoneArticle Published on 2022-10-272023-06-12 Journal: Frontiers in Immunology [Category] B형 간염, Fulltext, [키워드] Alanine aminotransferase (ALT) antiviral therapy Chronic hepatitis B (CHB) grey zone (GZ) indication Liver Biopsy significant liver injury. [DOI] 10.3389/fimmu.2022.1035923 PMC 바로가기
Nafamostat Mesylate for Treatment of COVID-19 in Hospitalised Patients: A Structured, Narrative ReviewArticle Published on 2022-10-012022-11-15 Journal: Clinical pharmacokinetics [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome addition Antithrombotic Antiviral antiviral potency benefit cell line cellular clinical Clinical outcome clinical study clinical trial clinically Coronavirus-2 COVID-19 disease Disseminated intravascular coagulation drug effective Efficacy enzyme human cells human lung hypothesised indication inhibitory concentration intravenous investigated Japan Laboratory mesylate nafamostat Nafamostat mesylate narrative patients with moderate pharmacokinetic protease recruitment Remdesivir repurposing review robust SARS-CoV-2 serine 2 severe COVID-19 TMPRSS2 transmembrane treatment for COVID-19 viral entry [DOI] 10.1007/s40262-022-01170-x PMC 바로가기
Iron status and the risk of sepsis and severe COVID-19: a two-sample Mendelian randomization studyArticle Published on 2022-09-282022-11-15 Journal: Scientific Reports [Category] 바이오마커, [키워드] 95% confidence interval analysis association Biomarker COVID-19 ferritin higher risk Hospitalization Hospitalized Inconclusive increase in increased risk indicated indication iron iron binding capacity management men mendelian randomization observational study Odds ratio Pleiotropy risk Sepsis serum severe infections Standard deviation supported Transferrin with COVID-19 women [DOI] 10.1038/s41598-022-20679-6 PMC 바로가기
Long-term monitoring of SARS-CoV-2 RNA in sewage samples from specific public places and STPs to track COVID-19 spread and identify potential hotspotsCOVID-19 확산을 추적하고 잠재적인 핫스팟을 식별하기 위해 특정 공공 장소 및 STP의 하수 샘플에서 SARS-CoV-2 RNA의 장기 모니터링Article Published on 2022-09-102022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, [키워드] air airport analyzed Asymptomatic Brazil can be used caused Concentration COVID-19 COVID-19 cases death detect dissemination epidemiological epidemiological situation epidemiological surveillance Epidemiology FIVE greater highest hotspot identify indication Infection International airport Local local outbreaks much lower non-infected Outbreaks pandemic plant Public Public places RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA selected sentinel Sentinel sewage surveillance sewage Sewage treatment Sewage treatment plant SHC1 SHC2 Spread suggested Surveillance symptomatic Treatment Viral concentration viral concentrations Waterwater-based epidemiology. [DOI] 10.1016/j.scitotenv.2022.155959 PMC 바로가기 [Article Type] Article
Myopathy as a cause of fatigue in long-term post-COVID-19 symptoms: Evidence of skeletal muscle histopathology코로나19 이후 장기 증상에서 피로의 원인인 근병증: 골격근 조직병리학의 증거Article Published on 2022-09-012022-09-11 Journal: European journal of neurology [Category] COVID19(2023년), SARS, 변종, [키워드] ABC acute disease acute infection affected age analyzed Antigen basal lamina biopsy Capillaries capillary cells changes changes in COVID-19 symptoms Cytochrome C cytochrome c oxidase diagnosed disease electromyography electron microscopy evidence of expression fatigue fiber histological change histological changes histopathological Histopathology human leukocyte antigen indication indications Inflammation Injury less leukocyte long-term COVID Microscopy Mild mitochondrial Most patients muscle muscle biopsy muscle fiber muscle weakness muscular myalgia myopathic Myopathy Patient patients post-COVID syndrome. Quantitative reduced reported SARS-CoV-2 Skeletal muscle skeletal muscles Symptoms syndrome T lymphocyte T lymphocytes two patients variant variety weakness [DOI] 10.1111/ene.15435 PMC 바로가기 [Article Type] Article
Investigating disparity in access to Australian clinical genetic health services for Aboriginal and Torres Strait Islander people Research Published on 2022-08-242022-10-05 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] adjusted Adults baseline benefit Cancer females Genetic Health Service indication multivariate paucity of data Poisson Population populations Precision prenatal presenting Regression Torres Strait [DOI] 10.1038/s41467-022-32707-0 [Article Type] Research
Patients awaiting surgery for neurosurgical diseases during the first wave of the COVID-19 pandemic in Spain: a multicentre cohort studyObservational Study Published on 2022-08-172022-10-04 Journal: BMJ Open [Category] SARS, 임상, [키워드] adopted Adult surgery analysed Analysis Brain cerebrospinal fluid Cerebrovascular disease cohort study Community covariate COVID-19 COVID-19 pandemic CSF degenerative Deterioration determine died disease disorder disorders enrolled evaluate the effect Factor First wave functional incidence independent indication mechanical ventilation Mortality multicentre multivariate logistic regression neurosurgery number of infected outbreak outcome Paediatric neurosurgery. pandemic Patient performed Primary outcome public health radiological Retrospective study SARS-CoV-2 SARS-COV-2 infection second secondary outcome Spain surgical Tumours Two patient worsening [DOI] 10.1136/bmjopen-2022-061208 PMC 바로가기 [Article Type] Observational Study
Nanoparticles in clinical trials of COVID-19: An updateReview article Published on 2022-08-012022-10-05 Journal: International journal of surgery (London, England) [Category] 변종, 임상, 치료제, [키워드] approved benefit Bioavailability clinical trial clinical trials COVID-19 COVID-19 disease COVID-19 vaccination drug delivery drugs effective effective vaccine Efficacy Efficiency effort example exhibit globe highlighting Immunity Immunotherapy inaccessible increasingly indication Infectious disease investigated long-lasting medication Medicine Medicines nanoparticle Nanoparticles outbreak outcomes pandemic provide reducing researcher Safe SARS-CoV-2 antigen Strategy therapeutic therapy Toxicity Treatment Vaccine Vaccines WHO World Health Organization [DOI] 10.1016/j.ijsu.2022.106818 [Article Type] Review article
A computational approach to drug repurposing using graph neural networksResearch article Published on 2022-08-012022-10-05 Journal: Computers in biology and medicine [Category] Coronavirus, 신약개발, [키워드] approach approved drug approved drugs baseline complex interaction Computational pharmacology coronavirus disease COVID-19 database dataset Diseases drug drug repositioning Drug repurposing drugs Efficacy generate Genes Graph neural networks heterogeneous identify indication Link prediction majority predict predicted representing the disease Treatment [DOI] 10.1016/j.compbiomed.2022.105992 [Article Type] Research article